A heuristic model for working memory deficit in schizophrenia
نویسندگان
چکیده
منابع مشابه
Working memory deficit as a core neuropsychological dysfunction in schizophrenia.
OBJECTIVE This study tested the hypothesis that impaired working memory is a core deficit underlying multiple neuropsychological deficits in schizophrenia patients. METHOD The subjects were 27 men with stable chronic schizophrenia treated with atypical antipsychotics and 38 normal participants. They were assessed with a battery of neuropsychological tests. Verbal working memory was measured w...
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Working memory deficits in schizophrenia are key cognitive features of the disorder and have been demonstrated to involve a circuit of brain regions. Here we model this circuitry with a connectionist model representing 3 key processing areas of the circuitry: anterior cingulate gyrus (ACG), dorsal lateral prefrontal cortex (DLPFC), and parietal cortex. The model adapts to a stream of unique inp...
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Spatial working memory function was assessed in schizophrenia patients, hypothetically 'psychosis-prone' individuals who report unusual perceptual experiences and normal control subjects with an oculomotor delayed response task. Past studies point to the important role of dorsolateral prefrontal system in spatial working memory deficits of schizophrenia patients. In order to better understand t...
متن کاملA computational model for spatial working memory deficits in schizophrenia.
Cognitive deficits in schizophrenia have been hypothesized to be caused by altered synaptic transmission in circuits of the prefrontal cortex. 2 main hypotheses have been put forward: reduced inhibition and hypofunctional NMDA receptors. Recently, Lee et al. (2008) found that spatial working memory deficits in schizophrenic patients include a disproportionately high incidence of high-confidence...
متن کاملWorking Memory in Schizophrenia
Background: Working memory has been reported to be impaired in schizophrenia, but there are inconsistencies in the literature. Therefore, we undertook the current study with the objective of assessing both auditory and visuospatial working memory tasks in a sample of schizophrenia patients in comparison to normal controls, and its correlation with psychopathology. Method: The sample comprised o...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2016
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2016.04.031